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An Efficient Chitosan/Silica Composite Core–Shell Microspheres-Supported Pd Catalyst for Aryl Iodides Sonogashira Coupling Reactions
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posted on 2016-12-07, 00:00 authored by Qing Cui, Hong Zhao, Guangsheng Luo, Jianhong XuMonodispersed chitosan/silica core–shell
microspheres-supported
Pd catalysts were prepared by a simple and affordable microfluidic
device. Merely 5 mg of supported Pd catalyst (1 wt %) showed superior
capability in Sonogashira coupling reactions between various aryl
iodides and terminal alkynes in a mild environment (ligand-free, copper-free,
amine-free, water–ethanol as solvent at 65 °C) even after
eight cycles of use. These novel porous composite microspheres provide
a new carrier to reduce the loading, enhance the activity, and increase
the stability of noble metal catalyst.