jz8b01998_si_001.pdf (1.32 MB)
An Alternative Approach to Estimate Solute Concentration: Exploiting the Information Embedded in the Solid Phase
journal contribution
posted on 2018-07-13, 19:47 authored by Stefan Bötschi, Ashwin Kumar Rajagopalan, Manfred Morari, Marco MazzottiThe
solute concentration in crystallization processes is generally
estimated by observing properties of the liquid phase. Here, a novel
method for online estimation of the change in the solute concentration
caused by seeded batch crystallization or dissolution of a population
of crystals in suspension is presented. The method is based on multiprojection
imaging to track variations in the total solid volume of the population,
thus enabling inference of the solute concentration through the mass
conservation constraint. The solute concentration estimates obtained
in this way are validated by using them to measure the solubilities
of β l-glutamic acid and vanillin in water within certain
temperature ranges and comparing them to literature data. The presented
method shows promise in estimating the solute concentration reliably
under circumstances where employing conventional techniques is challenging.