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Alternative total synthesis of (+)-aspicilin
journal contribution
posted on 2018-06-08, 18:37 authored by Sridhar Musulla, Bharathi Kumari Y, Mahesh Madala, Srinivasa Rao A, Vema Venkata NareshThe total synthesis of an 18-membered polyhydroxylated macrolide (+)-Aspicilin was accomplished starting from commercially available enantiopure propylene oxide and D-(+)-gluconolactone by asymmetric synthetic approach. The key reactions involved are Witttig reaction, Sharpless asymmetric dihydroxylation, and Yamaguchi macrolactonization.