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Aldgamycins J–O, 16-Membered Macrolides with a Branched Octose Unit from Streptomycetes sp. and Their Antibacterial Activities
journal contribution
posted on 2016-09-30, 19:33 authored by Chuan-Xi Wang, Rong Ding, Shu-Tai Jiang, Jin-Shan Tang, Dan Hu, Guo-Dong Chen, Feng Lin, Kui Hong, Xin-Sheng Yao, Hao GaoSix new 16-membered macrolides with
a rare branched octose unit,
aldgamycins J–O (1–6), along
with two known compounds, swalpamycin B (7) and chalcomycin
(8), were isolated from Streptomyces sp. HK-2006-1. Their structures were determined by detailed spectroscopic
and X-ray crystallographic analysis. Natural products containing branched
sugar units are rare. Aldgaropyranose and decarboxylated aldgaropyranose
are branched octoses, specifically aldgarose-type branched octose.
Until now, only 11 compounds have been reported to contain an aldgarose-type
branched octose. The discovery of aldgamycins J–O (1–6) adds new members of this type of natural
product. All the compounds (1–8)
herein were tested for antimicrobial activities against Gram-positive Staphylococcus aureus 209P, Gram-negative Escherichia
coli ATCC0111, and two fungi, Candida albicans FIM709 and Aspergillus niger R330. Most of these
compounds showed antibacterial activity against S. aureus. Their preliminary structure–activity
relationships are proposed.
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Streptomycetes spS . aureusBranched Octose UnitStreptomyces spsugar unitsCandida albicans FIM 709Natural productsHK -2006-1.ATCCAntibacterial Activities11 compoundsGram-positive Staphylococcus aureus 209 Paldgarose-typealdgamycinantimicrobial activitiesAspergillus niger R 330.octose unitswalpamycin Bdecarboxylated aldgaropyranose16- membered macrolides
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