Fig 2.tif (1.24 MB)
AgoshRNA molecules and CCR5 target sequences.
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posted on 2017-05-24, 17:40 authored by Elena Herrera-Carrillo, Ben Berkhout13 AgoshRNAs against human CCR5 were designed. The target sequences in CCR5 mRNA (GenBank: AY874120) are shown with the position in subscript. The predicted structure of the AgoshRNA molecules by MFold is shown in the third column with the guide sequence boxed in grey and the bottom mismatch A C boxed in black. The potent shRNA sh1005 was included as positive control.
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infection Allogeneic transplantationDicer-independent RNAi pathwaysNovel AgoshRNA moleculesCCR 5 co-receptorAgoshRNA designspotently downregulated CCR 5 expressionCCR 5 mRNAPBMCAgoshRNA processing yieldsCCR 5 knockdownCCR 5 tropic HIVShort hairpin RNAT cell developmentcell growth assayT cellsCCR 5 expression
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