Advantageous Use of tBu2P-NP(iBuNCH2CH2)3N in the Hiyama Coupling of Aryl Bromides and Chlorides

Raders, Steven M.; Kingston, Jesudoss V.; Verkade, John G.

doi:10.1021/jo902338w.s001

jo902338w_si_001.pdf (8.48 MB)

Advantageous Use of ^tBu₂P-NP(ⁱBuNCH₂CH₂)₃N in the Hiyama Coupling of Aryl Bromides and Chlorides

journal contribution

posted on 2010-03-05, 00:00 authored by Steven M. Raders, Jesudoss V. Kingston, John G. Verkade

An efficient catalytic route to biaryls by employing (generally) only 0.25 mol % of Pd(OAc)₂ and 0.5 mol % of 1 in the Hiyama coupling reaction is reported. High yields for electron-rich, -neutral, and -deficient aryl chlorides are obtained. A variety of phenylsiloxanes undergo coupling with aryl bromides and chlorides with low Pd(OAc)₂/1 loadings.