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Advancing Solutions to the Carbohydrate Sequencing Challenge
journal contribution
posted on 2019-08-21, 19:37 authored by Christopher
J. Gray, Lukasz G. Migas, Perdita E. Barran, Kevin Pagel, Peter H. Seeberger, Claire E. Eyers, Geert-Jan Boons, Nicola L. B. Pohl, Isabelle Compagnon, Göran Widmalm, Sabine L. FlitschCarbohydrates possess a variety of
distinct features with stereochemistry
playing a particularly important role in distinguishing their structure
and function. Monosaccharide building blocks are defined by a high
density of chiral centers. Additionally, the anomericity and regiochemistry
of the glycosidic linkages carry important biological information.
Any carbohydrate-sequencing method needs to be precise in determining
all aspects of this stereodiversity. Recently, several advances have
been made in developing fast and precise analytical techniques that
have the potential to address the stereochemical complexity of carbohydrates.
This perspective seeks to provide an overview of some of these emerging
techniques, focusing on those that are based on NMR and MS-hybridized
technologies including ion mobility spectrometry and IR spectroscopy.
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IR spectroscopyoverviewion mobility spectrometryMonosaccharide building blocksperspectiveaspecttechnologyinformationvarietytechniquerolestereochemistryglycosidic linkagesfunctionstereodiversitySolutionanomericityCarbohydrate Sequencing Challenge Carbohydratesadvancechiral centersNMRdensitycarbohydrate-sequencing methodstereochemical complexityregiochemistryMS-hybridized technologies
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