Adenosine A2B Receptor Pharmacology and its Role in Pathophysiology

2017-08-14T23:55:03Z (GMT) by ELIZABETH ANN VECCHIO
The adenosine A<sub>2B</sub> receptor is an important but poorly understood drug target. This thesis investigated new paradigms of adenosine A<sub>2B</sub> receptor signalling and behaviour and identified drugs that could selectively promote beneficial outcomes in prostate cancer cells and cardiac fibroblasts. This information helps to inform how targeting the adenosine A<sub>2B</sub> receptor may be used as a treatment for prostate cancer and cardiovascular disease.