Additional file 9: of Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation

Figure S7. NEAT1 is a TP53 target gene in HCC. A. The expression of NEAT1 was higher in TP53 wild-type tissues (n = 26) than in the TP-53 mutant liver tissues (n = 14). B. Treatment with Nutlin-3a resulted in higher NEAT1 levels in TP53 wild-type Hep-G2 and SK-hep-1 cells but not in TP53 mutant Huh7 and HCCLM3 cells. C. Western blot analysis determined TP53 was upregulated following NEAT1 knockdown in SK-Hep-1 and Hep-G2 cells. D. Western blot analysis determined p21 and Bax was upregulated following NEAT1 knockdown in SK-Hep-1 and Hep-G2 cells. Data are expressed as mean ± SD of three independent experiments. Statistical significance was concluded at *P < 0.05, **P < 0.01, NS represents no statistical significance. (TIF 530 kb)