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Additional file 7: Figure S2. of Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

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posted on 2016-10-04, 05:00 authored by Thomas Southworth, Jonathan Plumb, Vandana Gupta, James Pearson, Isabel Ramis, Martin Lehner, Montserrat Miralpeix, Dave Singh
Comparison of % inhibition of IFNγ, IL-13 and IL-17 for dexamethasone, tofacitinib and PIK-294. BAL cells from asthma patients (n = 12) and healthy subjects (n = 11) were treated with dexamethasone, tafacitinib or PIK-294 for 1 h before being stimulated with antibodies against CD3 and CD28 to induce a TCR-specific response. Cytokines were measured by ELISA and data is presented as the mean (+/− SEM) % inhibition in relation to the stimulated no drug control. (PPTX 742 kb)

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