40478_2017_503_MOESM6_ESM.pdf (3.26 MB)
Additional file 6: Figure S4. of Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study
journal contribution
posted on 2018-01-08, 05:00 authored by Ignazio Cali, Mark Cohen, Stéphane Haїk, Piero Parchi, Giorgio Giaccone, Steven Collins, Diane Kofskey, Han Wang, Catriona McLean, Jean-Philippe Brandel, Nicolas Privat, Véronique Sazdovitch, Charles Duyckaerts, Tetsuyuki Kitamoto, Ermias Belay, Ryan Maddox, Fabrizio Tagliavini, Maurizio Pocchiari, Ellen Leschek, Brian Appleby, Jiri Safar, Lawrence Schonberger, Pierluigi GambettiQuantitative estimates of Thioflavin S-positive Aβ CP affecting the cerebral cortex in subjects with iCJD and sporadic AD (sAD). A: the density of Aβ CP, expressed as the percentage of cerebral cortex area occupied, was 5 times greater in subjects with sAD than in iCJD. B: size of Aβ CP (N=500), expressed as diameter, was greater in patients with sAD than in those with iCJD. C and D: representative microscopic fields showing fewer and smaller CP (arrows) in iCJD (C) than sAD (D) where cluster of very large CP (dashed square) could be detected. Bar graphs are expressed as mean ± standard error of the mean (SEM) in A or as mean ± standard deviation in B. Student's t-test (two-tailed). (PDF 3338 kb)
