Additional file 5: of A multilevel pan-cancer map links gene mutations to cancer hallmarks

Figure S4. Connectivity in the map between the 25 most frequently mutated genes and pathways. Similar to Additional file 2: Figure S1 but showing the connectivity for only the 25 most frequently mutated genes. E2F3, E2F transcription factor 3; RB1, retinoblastoma 1; CCND1, cyclin D1; CDKN2A, cyclin-dependent kinase inhibitor 2A; APOB, apolipoprotein B; TNIK, TRAF2 and NCK interacting kinase; LRP2, low-density lipoprotein receptor-related protein 2; EPHB3, EPH receptor B3; FBXW7, F-box and WD repeat domain containing 7; DVL3, dishevel segment polarity protein 3; RELN, reelin; APC, adenomatous polyposis coli; NOTCH1, notch 1; FGFR1/FLG, fibroblast growth factor receptor 1/filaggrin; FADD, Fas (TNFRSF6)-associated via death domain; PTEN/TEP1, phosphatase and tensin homolog/telomerase-associated protein 1; CTTN, cortactin; EGFR, epidermal growth factor receptor; PLD1, phospholipase D1, phosphatidylcholine-specific; TP53, tumor protein p53; EP300, E1A-binding protein p300; KRAS, Kirsten rat sarcoma viral oncogene homolog; CTNNB1, catenin (cadherin-associated protein), beta 1; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; PIK3R1, phosphoinositide-3-kinase, regulatory subunit 1 (alpha).