Additional file 5: Figure S3. of MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses

Experimental design for probiotic stability studies in gnotobiotic mice. Seven adult germ-free mice were gavaged with 13 Clostridia strains from the VE202 probiotic cocktail [24]. Five mice were maintained on a standard high-fiber diet for 5 weeks, after which mice were switched to a low-fiber diet for 2 weeks and then switched back to the high-fiber diet for another 2 weeks; an additional two mice were inoculated with the same strains but were not subjected to the low-fiber dietary perturbation. Fecal pellets were collected at days 1–21 (daily), 23, 25, 27, 29, 31, 33, 35–60 (daily), 62, 63, and 65 for the five mice receiving the low-fiber dietary perturbation and at days 1–21 (daily), 23, 25, 27, and 29 for the two mice not receiving the perturbation. (PDF 42 kb)