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Additional file 5: Figure S2. of Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms

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posted on 2017-01-13, 05:00 authored by Marina Badenes, Alexandre Trindade, Hugo Pissarra, Luís Lopes-da-Costa, António Duarte
Confirmation of Dll4 knockout in endothelial-specific and ubiquitous Dll4 Apc Min/+ mutant tumors. RT-PCR analysis of the Dll4/Notch effector Hey2 relative expression in the Apc Min/+ endoDll4 -/- intestinal tumors and of Dll4 relative expression in the Apc Min/+ ubiqDll4 -/- intestinal tumors, both from mice at 18 weeks of age. One experiment with n = 3 per group. The expression of Hey2 and Dll4 was normalized to Pecam-1. *P < 0.05. (PDF 71 kb)

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Fundação para a Ciência e Tecnologia, Portugal

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