Additional file 4: of Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits

Table S3. Rank and fold change of enrichment of biological hallmarks at putative bovine TAD boundaries. This table shows the level of enrichment of each biological hallmark at putative bovine TAD boundaries. The level of enrichment for each biological signal is measured by the number of base pairs that a biological signal overlapping with the TAD boundary. Presented are two types of TAD boundaries for each TAD set, differed by whether a boundary is considered present if two neighbouring putative bovine TADs overlap each other by 1 bp. “< 0.0001” denotes the degree of overlap between the biological hallmark and TAD boundaries larger than all permuted cases. (A) The degrees of enrichment of all biological signals at the boundary of each TAD set are shown. (B) The degrees of enrichment of each pattern of CTCF binding motifs at the boundary of each TAD set are shown. Each motif pattern has a unique motif number defined by the FIMO output. Each best possible match motif is manually compared with the MEME-ChIP to assess whether the matched motif is previously reported. (XLSX 54 kb)