Additional file 4: of Generalized enrichment analysis improves the detection of adverse drug events from the biomedical literature

Coverage of ADEs in MEDLINE. Coverage of adverse drug events in MEDLINE differs significantly across the four outcomes in OMOP. In particular for “Acute myocardial infarction”, only 16 out of the 33 positive test cases (48 %) were found in our set of candidate drug – adverse event pairs from the literature (at low abstraction). For 17 out of 33 drugs, there was not a single article mentioning a relation between drug and acute MI, and hence no signal could be detected. (XLSX 9 kb)