Additional file 4: Figure S4. of Orchestrated activation of mGluR5 and CB1 promotes neuroprotection

MPEP and AM251 action on CDPPB- and JZL184-mediated protection of synaptic terminals. Shown are laser-scanning confocal micrographs depicting Alexa Fluor 488-conjugated anti-PSD95 antibody (green), Alexa Fluor 546-conjugated anti-syntaxin 1A antibody (red) and DAPI (blue) in neurons that were treated with 50 μM glutamate (glut) in the presence of 100 nM CDPPB + 1 μM MPEP (A), 100 nM CDPPB + 10 nM AM251 (B), 10 nM JZL184 + 1 μM MPEP (C) and 10 nM JZL184 + 10 nM AM251 (D) for 4 h. Scale bar = 20 μM. (TIF 8576 kb)