Additional file 4: Figure S1. of Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

Southworth, Thomas; Plumb, Jonathan; Gupta, Vandana; Pearson, James; Ramis, Isabel; Lehner, Martin; Miralpeix, Montserrat; Singh, Dave

doi:10.6084/m9.figshare.c.3632936_D6.v1

12931_2016_436_MOESM4_ESM.pptx (211.88 kB)

Additional file 4: Figure S1. of Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

presentation

posted on 2016-10-04, 05:00 authored by Thomas Southworth, Jonathan Plumb, Vandana Gupta, James Pearson, Isabel Ramis, Martin Lehner, Montserrat Miralpeix, Dave Singh

Cytotoxic effects of PIK-294, tofacinib and dexamethasone. PBMCs from healthy subjects (n = 3) were treated with PIK-294, tofacinib or dexamethasone for 1 h prior to TCR-stimulation for 72 h. Cytotoxicity was assessed by LDH assay (A) or propidium iodide flow cytometry assay (B). Cytotoxic effects were assessed by 1-way ANOVA with Dunnett’s post-hoc test against the no drug DMSO control. All non-significant. (PPTX 211 kb)