Additional file 3: Figure S3. of Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes

Representative results of correlation analysis. Significant inverse correlations between DNA methylation levels and mRNA expression levels were detected for the other five DME genes (CYP1A2, CYP2D6, GSTM5, GSTT1, and SULT1A1; p < 0.05, Spearman’s rank correlation test). The mRNA expression level, shown as the vertical axis, was normalized to the level of ACTB mRNA (set as 100 %). CpG sites with significant correlation are indicated by asterisks in the methylation map for each gene. CpG sites showing β R values of more than 0.296 are indicated by circles. (PDF 54.3 KB)