Additional file 3: Figure S3. of A T-type channel-calmodulin complex triggers ÎąCaMKII activation

Cav3.1 channel pore mutant constructs. A single amino acid mutation of Cav3.1 creates a pore mutant that does not conduct calcium current. Shown are representative recordings and the associated I-V plot of a transient low voltage-activated current measured in the Cav3.1 mutant expressed in tsA-201 cells. Superimposed recordings and plot illustrate the records obtained in normal bathing medium and following substitution of sodium in the bathing medium by 130 NMDG. (PDF 351 kb)