Additional file 3: Figure S2. of High-throughput validation of ceRNA regulatory networks

The effect of predicted PTEN ceRNA regulators by each of the three methods. Average PTEN mRNA fold change following shRNA-mediated silencing of its predicted regulators, as predicted by each ceRNA inference method including random assay selection, and inferences by Hermes, MuTaME, and cefinder. P values were calculated by comparing fold changes to random assay selection with PTEN expression profiling, using the Student’s T-test (two-tailed). Average fold changes were normalized to the random assay selection. Bars show standard errors; * stands for p < 0.05; ** for p < 0.01; *** for p < 0.001. (PDF 922 kb)