Additional file 2: Figure S1. of Tissue-aware RNA-Seq processing and normalization for heterogeneous and sparse data

PCoA analysis of multiple tissues on Y-chromosomal genes can highlight poor sex annotation, related to Fig. 1 and misannotation section. Scatterplots of the first and second principal components from principal component analysis on all major tissue regions. We plotted data from 13 tissue regions from the GTEx consortium, coloring the annotated sex of each sample. Enlarged is sample GTEX-11ILO that clusters with male samples in every tissue despite being annotated as being from a female; we later learned that this research subject was genetically male. (PDF 240 kb)