Additional file 2: Figure S1. of Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

Scatterplot showing a strong positive correlation between two independent measures of ACE-2 activity in brain tissue samples. ACE-2 was measured using either a commercially available ACE-2 activity assay kit (SensoLyte® 390) or an ACE-2 fluorogenic peptide substrate (Mca-APK[Dnp]) in the presence of a selective ACE-2 inhibitor, MLN4760 (10 μM). The solid inner line indicates the best-fit linear regression, and the outer lines the 95% confidence intervals. Each point represents a separate brain. ****P < 0.0001. (TIF 26 kb)