Additional file 1: of TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Increased tau pathology in 6-month hTau;Trem2−/− mice. A Western blot shows increased conformation specific anti-tau antibody MC1 reactivity in hTau;Trem2 −/− compared to hTau controls. B Increased ratio of Iba1 reactivity to AT8 Tau reactivity within cortices of hTau;Trem2 −/− mice. At least two independent experiments were performed for each analysis, n = 4–6 mice per genotype; equal males and females. Error bars represent SEM. *, P < 0.05, **, P < 0.01, ***, P < 0.001. (PDF 956 kb)