Additional file 1: of TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Bemiller, Shane; McCray, Tyler; Allan, Kevin; Formica, Shane; Xu, Guixiang; Wilson, Gina; Kokiko-Cochran, Olga; Crish, Samuel; Lasagna-Reeves, Cristian; Ransohoff, Richard; Landreth, Gary; Lamb, Bruce

doi:10.6084/m9.figshare.c.3905836_D1.v1

13024_2017_216_MOESM1_ESM.pdf (956.21 kB)

Additional file 1: of TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

journal contribution

posted on 2017-10-16, 05:00 authored by Shane Bemiller, Tyler McCray, Kevin Allan, Shane Formica, Guixiang Xu, Gina Wilson, Olga Kokiko-Cochran, Samuel Crish, Cristian Lasagna-Reeves, Richard Ransohoff, Gary Landreth, Bruce Lamb

Increased tau pathology in 6-month hTau;Trem2−/− mice. A Western blot shows increased conformation specific anti-tau antibody MC1 reactivity in hTau;Trem2 −/− compared to hTau controls. B Increased ratio of Iba1 reactivity to AT8 Tau reactivity within cortices of hTau;Trem2 −/− mice. At least two independent experiments were performed for each analysis, n = 4–6 mice per genotype; equal males and females. Error bars represent SEM. *, P < 0.05, **, P < 0.01, ***, P < 0.001. (PDF 956 kb)