Additional file 1: of Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches

Supplemental Information. Additional information including supporting figures, the generalized conceptual model for an organ with metabolism, detailed descriptions of the toxicokinetic models, a comparison of the 7C model to the original Zebrafish PBTK on which it was based, results of sensitivity analyses of the PBTK models, detailed descriptions of the reverse toxicokinetic models, an analytical approach to determining the influence of architecture on steady state concentrations, and an approximation of the departure of in vitro data from control levels. (PDF 1762 kb)