Additional file 1 of Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics

The file provides appendices describing the mathematical details of our analysis. It includes discussions on nondimensionalization and parameter estimations used in our model. Analyses of the nullcline structure and the parameter space are also provided and the effect of stress onset timing on initial stress response is described in detail. Finally, a possible form of cortisol dependent I ext is illustrated with its implications on model behavior. (PDF 2099 kb)