Additional file 1: Supplementary Table 1. of PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition

Characteristics of isoform-selective PI3K inhibitors. Supplementary Table 2. Characteristics of JNK inhibitor SP600125. Supplementary Table 3. Combination index (CI) for cell viability in GBM cell line U-87 MG in the combination of PIK-75 and SP600125 (n = 3). Supplementary Fig. 1: Half-maximal inhibitory concentration (IC50) values of PIK-75, TGX-221, CAL-101 and SP600125 on glioblastoma cell line U87-MG. Supplementary Fig. 2. Effects of PIK-75, TGX-221, CAL-101 and SP600125 on cell viability of glioblastoma cell line U-373 MG. Supplementary Fig. 3. Combination effects of isoform-selective PI3K inhibitors and SP600125 on proliferation of glioblastoma cells and normal human astrocytes. Supplementary Fig. 4. Combination effects of isoform-selective PI3K inhibitors and SP600125 on migration of U-373 MG glioblastoma cells. Supplementary Fig. 5. Combination effects of isoform-selective PI3K inhibitors and SP600125 on invasion of U-373 MG glioblastoma cells. Supplementary Fig. 6. Combination effects of isoform-selective PI3K inhibitors and SP600125 on glioblastoma U-87 MG cell apoptosis. (DOC 3768 kb)