Additional file 1: Figures S1–S3 and Tables S1–S3. Figure S1. of A novel TRPM8 agonist relieves dry eye discomfort

Cornea, but not conjunctiva, is highly innervated by TRPM8 sensory fibers. Figure S2. The cell bodies of sensory fibers innervating the upper eyelid and cornea are located in the V1 ophthalmic branch of the trigeminal ganglion. Figure S3. Flow diagram for the design of Expt 1. Figure S4. Flow diagram for the design for Expt 2. Table S1. EC50 and relative potency of compounds on TRPM8. Table S2. Baseline characteristics of the enrolled subjects in Expt 1. Table S3. Baseline characteristics of the enrolled subjects in Expt 2. (DOCX 4087 kb)