Additional file 1: Figure S5. of Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials

Forest plot for ICU mortality. Data from 11 trials (n = 1487 patients) were included, analyzed using the random effects model. The risk of death during the ICU stay was similar in both groups. Figure S6. Forest plot for ICU length of stay. Data from 11 trials (n = 744 patients) were included, analyzed using the random effects model. The duration of ICU stay was similar in both groups. Figure S7. Sensitivity analysis for clinically important bleeding, excluding trials published as abstracts, shows similar results to the primary analysis. Figure S8. Funnel plot for clinically important bleeding outcome. Visual inspection does not show publication bias and the result for the Egger test was –0.69 (95 % CI –2.44, 0.84; P = 0.28). Figure S9. Funnel plot for pneumonia outcome. Visual inspection does not show publication bias. Figure S10. Funnel plot for ICU mortality outcome. Visual inspection does not show publication bias. (DOCX 1123 kb)