Additional file 1: Figure S1. of S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis

S100A8/A9 protein levels are systemically elevated in the serum during early CiOA. Systemic levels of S100A8/A9 protein in serum of WT mice are increased early during CiOA compared to saline-injected control mice, measured using ELISA. Data represent mean ± SD of five individual mice per group per time point. *Significantly different from saline-injected control (*p < 0.05, **p < 0.01, ***p < 0.001). Figure S2. Expression of adhesion molecules is lower in the BM of WT mice, compared to S100a9-/- mice, at CiOA day 7. mRNA expression of several adhesion molecules is lower in the BM of S100a9-/- mice compared to WT mice at CiOA day 7. Data represent mean ± SD of five individual mice. *Significantly different from saline-injected control (*p < 0.05, **p < 0.01, ***p < 0.001). (PPT 142 kb)