Additional file 1: Figure S1. of Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance

Additional RT-qPCR, RNA-seq and patient survival curve data. Figure S2 Additional GO term analysis for the SY5Y-MYCN RNA-seq data. Figure S3 Additional ITR analysis for the SY5Y-MYCN RNA-seq data. Figure S4 Additional data showing that RA and MYCN overexpression drive opposing activation dynamics of their downstream transcriptional regulators. Figure S5 Additional TGF-β/SMAD MYCN ChIP-seq and interactome data. Figure S6 Additional data showing TGF-β pathway components targeted by the small molecule kartogenin are predictive of neuroblastoma patient outcome. Figure S7 Additional kartogenin and retinoic acid cell viability and apoptosis data. (PDF 10467 kb)