Additional file 1: Figure S1. of Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells

Addition of exogenous palmitate does not increase cellular permeability of SKBR3 cells. Figure S2: Detailed results of the GO-term enrichment analysis for MCF7 cells using the DAVID Bioinformatics resource. Figure S3: Detailed results of the GO-term enrichment analysis for SKBR3 cells using the DAVID Bioinformatics resource. Figure S4: Enrichment map illustrating gene member overlap in the enriched GO-terms for SKBR3 cells treated with palmitate. Figure S5: Gene set enrichment analysis of significantly altered transcripts in SKBR3 cells after palmitate treatment. Figure S6: Exogenous palmitate does not alter the proteasome activity in HER2/neu-positive SKBR3 breast cancer cells. Figure S7: Expression of ER stress markers in HER2/neu-positive breast cancer cells upon treatment with palmitate. Figure S8: Alterations of ER stress regulators associate with alterations of regulators of the lipogenic phenotype previously described in HER2/neu-positive breast cancer cell lines. Figure S9: Her2/neu expression by itself has relatively minor effects on ER stress. Table S1: Primers used in expression analysis of ER stress markers. (DOCX 2241 kb)