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12943_2017_710_MOESM1_ESM.ppt (4.52 MB)
Additional file 1: Figure S1. of MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis
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posted on 2017-08-22, 05:00 authored by Yan Yang, Lili Ding, Qun Hu, Jia Xia, Junjie Sun, Xudong Wang, Hua Xiong, Deepak Gurbani, Lianbo Li, Yan Liu, Aiguo Liu(A) A549 and H1975 cells were transfected with miR-cont or miR-218. Protein levels of EGFR were examined by western blotting 36Â h after transfection. (B) A549 and H1975 cells were transfected with siR-cont or siR-EGFR. Protein levels of EGFR and pSTAT3 were examined by western blotting 36Â h after transfection. (C) Cell proliferation in H1975 and A549 cells was determined 48Â h after transfection of siR-EGFR or siR-control. Figure S2. Correlation of IL-6R/JAK3 and miR-218 in patients with lung adenocarcinoma in TCGA cohort. (PPT 4631 kb)