Additional file 1: Figure S1. of Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

Lipoxin A4 reduces mechanical allodynia induced by spinal cord hemisection in rats. A, C, Following SCI, adult rats develop mechanical hypersensitivity in both ipsilateral and contralateral hindpaws. Frequency of responses is reduced with LXA4 administration, compared to vehicle-treated group. B, D, The area under the curve of frequency of paw withdrawal responses to mechanical stimulation of ipsilateral and contralateral paw over time. Results are presented as mean ± SEM. * denotes p < 0.05 when comparing to sham-operated group. # denotes p < 0.05 when comparing with vehicle-treated group (two-way ANOVA followed by Bonferroni; n = 8 rats/group). (TIF 2197 kb)