Additional file 13: of Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population

Figure S8. The effects of TP53, ZNF750, CDC27 and other clinical features on the activity of the “NpCpG” signature and the “AID/APOBEC-2” signature in the subtypes of ESCC. The somatic status and the genetic burden of TP53 influence the activities of the “NpCpG” signature (a) and the “AID/APOBEC-2” signature (b) in subtype 1 to 3, independent of other clinical features. And the somatic status and the genetic burden of ZNF750 influence the activities of the “NpCpG” signature (c) and the “AID/APOBEC-2” signature (d) in subtype 1 to 3, independent of other clinical features. The somatic copy number amplification and the genetic burden of CDC27 influence the activity of the “NpCpG” signature (e) and the “AID/APOBEC-2” signature (f) in subtype 1 to 3, independent of other clinical features. P values are based on multivariate linear regression analysis: *P < 0.05, **P < 0.01, ***P < 0.001. (PDF 892 kb)