Additional file 10: Figure S5. of Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

Glutathione peroxidase expression and the effect of ebselen. (A) Immunofluorescence to GPX7 in Wt and Vdac1 −/− MEF in Nx or Hx for 72 h. (B) Immunoblotting for HIF-1α of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia. (C) Proliferation of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia. (D) Viability of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia.