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journal contribution
posted on 30.10.2018 by Omar Ibrahim, Homood As Sobeai, Stephen Grant, Jean Latimer
Figure S3. Comparative Analysis of the 20 Canonical NER genes in the Staal dataset of only T-ALL patients. (A) In the early relapsers subgroup (n = 12) 12 genes were overexpressed at the time of relapse (gray bars, P = .371) versus diagnosis (black bars). One gene was significantly over expressed: ERCC1 (P = .029). (B) In the late relapsers subgroup (n = 1), 15 genes were overexpressed at relapse versus diagnosis (P = .025), because this group consists of a single patient statistical analysis at the gene level could not be assessed. (C) At diagnosis the early relapsers (gray bars, n = 13) versus late relapsers (black bars, n = 1), 10 genes were upregulated (P = 1.000). 2 genes were individually significantly overexpressed: CDK7 (P = .038) and ERCC6 (P = .040). (D) At relapse in early relapsers versus late relapsers, 2 genes were upregulated and 18 were downregulated so the pathway was significantly downregulated (P < .001). 2 genes were individually significantly overexpressed: ERCC6 (P = .041) and GTF2H3 (P = .032). (PDF 95 kb)


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