Activity of MMP-9 and MMP-2 and expression of IL-6 and IL-1β in lung tissue of Balb/c mice received mutated VP1u of B19V and HBoV.

Activity of (A) MMP-9 relative and MMP-2 in lung tissues of Balb/c mice received PBS, B19-VP1uD175A or HBoV-VP1uL48R protein. Lower panels reveal the ratio of MMP-9 activity relative to MMP-2 activity. Expression of (B) IL-6 and IL-1β proteins in lung tissues of Balb/c mice received PBS, B19-VP1uD175A or HBoV-VP1uL48R protein. Bars represent the relative protein amounts of IL-6 and IL-1β on the basis of β-actin. Similar results were observed in three repeated experiments, and * indicates the significant difference, P<0.05.