Acremostrictin, a Highly Oxygenated Metabolite from the Marine Fungus <i>Acremonium strictum</i>

The novel natural product acremostrictin (<b>1</b>) was isolated from the culture broth of <i>Acremonium strictum</i>, a marine fungus collected from a Choristida sponge off the coast of Korea. Structurally, acremostrictin is a tricyclic lactone of an unprecedented skeletal class based on combined spectroscopic and X-ray crystallographic analyses. The new compound exhibited weak antibacterial and moderate antioxidant activities.