Acremolin from <i>Acremonium strictum</i> is <i>N</i><sup>2</sup>,3-Etheno-2′-isopropyl-1-methylguanine, not a 1<i>H</i>‑Azirine. Synthesis and Structural Revision

2013-05-17T00:00:00Z (GMT) by Lawrence A. Januar Tadeusz F. Molinski
The first synthesis of the heterocyclic marine natural product, acremolin, is reported along with the revision of the structure from a 1<i>H</i>-azirine to a substituted <i>N</i><sup>2</sup>,3-ethenoguanine (5-methyl-7-isopropyl-4,5-dihydroimidazo[2,1-<i>b</i>]purine). Additional properties of acremolin are also described including its <sup>1</sup>H–<sup>15</sup>N-HMBC and fluorescence spectra.