Acremolin from Acremonium strictum is N2,3-Etheno-2′-isopropyl-1-methylguanine, not a 1H‑Azirine. Synthesis and Structural Revision

2013-05-17T00:00:00Z (GMT) by Lawrence A. Januar Tadeusz F. Molinski
The first synthesis of the heterocyclic marine natural product, acremolin, is reported along with the revision of the structure from a 1H-azirine to a substituted N2,3-ethenoguanine (5-methyl-7-isopropyl-4,5-dihydroimidazo[2,1-b]purine). Additional properties of acremolin are also described including its 1H–15N-HMBC and fluorescence spectra.