usbr_a_1497531_sm4071.pdf (99.56 kB)
A Testing Strategy With Adaptive Dose Selection and Two Endpoints
Version 2 2018-09-11, 20:41
Version 1 2018-07-19, 20:44
journal contribution
posted on 2018-09-11, 20:41 authored by Ekkehard Glimm, Mauritz Bezuidenhoudt, Angelika Caputo, Willi MaurerThe article deals with the design of a complex clinical trial with multiple doses of an experimental treatment tested against a control treatment, interim analyses and several endpoints characterizing treatment success. The closed test principle, methods from group sequential testing, and combination test methodology are combined to control the familywise error rate (FWER) when testing for treatment benefit. We also discuss strategies for utilizing the correlations between some of the relevant test statistics.