ppat.1006827.g007.tif (962.18 kB)
A proposed model showing the role of FgMyo1 in toxisome formation.
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posted on 2018-01-22, 18:36 authored by Guangfei Tang, Yun Chen, Jin-Rong Xu, H. Corby Kistler, Zhonghua MaTrichothecene biosynthesis enzymes (Tri proteins) are produced at a low level under toxin noninducing conditions. In toxin inducing conditions, FgMyo1 directly participates in remodeling the endoplasmic reticulum (ER) via the myosin-actin cytoskeleton to form the spherical and ovoid structures termed “Fusarium toxisomes.” In addition, FgMyo1 interacts with FgAsc1 indirectly to enhance the translation of Tri proteins. Phenamacril is able to suppress toxisome formation by inhibiting the ATPase activity of FgMyo1, and subsequently reduces the biosynthesis of DON in Fusarium graminearum.
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FgMyo 1toxisome formationFgAsc 1 resultsTri 1 translationmycotoxin biosynthesismyosinFgMyo 1 expressionFusarium head blightDON biosynthetic enzyme Tri 1actin-associated proteins FgPrk 1actin polymerization disruptor latrunculinFgMyo 1-interacting proteinDON biosynthetic enzymes Tri 1FgMyo 1-actin cytoskeletonFusarium toxisome formation Myosin-Imutation E 420K down-regulationribosome-associated protein FgAsc 1. Disruption
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