A phytochemical study of the Cuphea glutinosa from Southern Brazil: Na+,K+-ATPase activity inhibition and antioxidant properties

Zago, Adriana M.; Carvalho, Fabiano B.; Gutierres, Jessié Martins; Bohnert, Crystiani; da Cruz Fernandes, Marilda; Morandini, Liziane M.; Coelho, Helena S.; Fogaça, Aline O.; Andrade, Cinthia M.; Mostardeiro, Marco A.; Dalcol, Ionara I.; Morel, Ademir F.

doi:10.6084/m9.figshare.6292979.v1

gnpl_a_1477143_sm8094.pdf (1.19 MB)

A phytochemical study of the Cuphea glutinosa from Southern Brazil: Na⁺,K⁺-ATPase activity inhibition and antioxidant properties

journal contribution

posted on 2018-05-21, 11:12 authored by Adriana M. Zago, Fabiano B. Carvalho, Jessié Martins Gutierres, Crystiani Bohnert, Marilda da Cruz Fernandes, Liziane M. Morandini, Helena S. Coelho, Aline O. Fogaça, Cinthia M. Andrade, Marco A. Mostardeiro, Ionara I. Dalcol, Ademir F. Morel

This study investigated the antioxidant activity of Cuphea glutinosa (CG) and its effect on Na⁺, K⁺-ATPase from cardiac muscle. The ethanolic extract showed higher antioxidant capacity compared to aqueous and ethyl acetate fraction. Ethyl acetate fraction showed β-sitosterol-3-O-β-glucoside, kaempferol, quercetin, isoquercetin, gallic acid methyl ester, and gallic acid. The ethanolic extract also reduced the Na⁺,K⁺-ATPase activity. CG presented a promising antioxidant activity and inhibitory effect on the Na⁺, K⁺-ATPase activity, supporting biochemical evidences the popular use of this plant in the treatment of heart failure.