A novel sesquiterpene derivative with a seven-membered B ring from <i>Illigera aromatica</i>

<p>A novel sesquiterpene derivative with a seven-membered B ring, illigerine (<b>1</b>), along with four known compounds, 1-<i>epi</i>-chiliophyllin (<b>2</b>), 3,4-dihydroxyphenethyl alcohol (<b>3</b>), coniferyl alcohol (<b>4</b>) and phenylpropionic acid (<b>5</b>), were isolated from <i>Illigera aromatica</i> S. Z. Huang et S. L. Mo. Their structures were identified by 1D/2D NMR, HRESIMS and electronic circular dichroism spectra and the cytotoxic activity and inhibitory effect of NO production in LPS-stimulated RAW264.7 were also evaluated. This is the first report of sesquiterpene isolated from the genus <i>Illigera</i>.</p>