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A novel sesquiterpene derivative with a seven-membered B ring from Illigera aromatica

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posted on 2018-01-25, 13:51 authored by Jian-Wei Dong, Le Cai, Xue-Jiao Li, Yan Shu, Jia-Peng Wang, Zhong-Tao Ding

A novel sesquiterpene derivative with a seven-membered B ring, illigerine (1), along with four known compounds, 1-epi-chiliophyllin (2), 3,4-dihydroxyphenethyl alcohol (3), coniferyl alcohol (4) and phenylpropionic acid (5), were isolated from Illigera aromatica S. Z. Huang et S. L. Mo. Their structures were identified by 1D/2D NMR, HRESIMS and electronic circular dichroism spectra and the cytotoxic activity and inhibitory effect of NO production in LPS-stimulated RAW264.7 were also evaluated. This is the first report of sesquiterpene isolated from the genus Illigera.

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