A new isocoumarin from the aerial parts of <i>Aconitum gymnandrum</i>

<p>A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of <i>Aconitum gymnandrum</i>. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound <b>11</b> was obtained as a natural product for the first time, which was previously reported as a synthetic product. In addition, compounds <b>1</b>–<b>5</b>, <b>7</b> and <b>9</b> were tested for their cytotoxicity against four human cancer cell lines. The results showed that compounds <b>3</b>, <b>4</b> and <b>7</b> displayed cytotoxicity against lung cancer A549 and gastric cancer MGC80, respectively, whereas <b>5</b> and <b>9</b> showed selective cytotoxicity against hepatocellular carcinoma HepG2.</p>