A new indole-type alkaloid from the roots of <i>Clematis florida var. plena</i>

<p>One new indole-type alkaloid, <i>α</i>-L-rhamnopyranosyl-(1→6)-<i>β</i>-D- glucopyranosyl 6-methoxy-3-indolecarbonate (<b>1</b>), together with three known alkaloids (<b>2</b>–<b>4</b>), one aromatic acid (<b>5</b>) and five known saponins (<b>6</b>–<b>10</b>), was isolated from the roots of <i>Clematis florida var. plena</i>. Their structures were established by NMR spectroscopic analysis and acid hydrolysis. In <i>in vivo</i> anti-inflammatory activity, <i>n</i>-butanol extract was found to be potent against ear edema in mice, with inhibition rate of 48.7% at a dose of 800 mg/kg. Furthermore, compounds <b>8</b> and <b>9</b> obtained from the <i>n</i>-butanol extract exhibited significant anti-inflammatory activities with inhibition rates of 50.9% and 54.7% at a dose of 200 mg/kg.</p>