A new daphnane diterpenoid from Excoecaria venenata with inhibitory effect on human leukaemia HL-60 cells

Ning, De-Sheng; Peng, Li-yan; Lv, Shi-Hong; Li, Dian-Peng; Pan, Zheng-Hong

doi:10.6084/m9.figshare.1158969.v3

gnpl_a_953498_sm9036.doc (4.02 MB)

A new daphnane diterpenoid from Excoecaria venenata with inhibitory effect on human leukaemia HL-60 cells

Version 3 2015-05-06, 14:43

Version 2 2015-05-06, 14:43

Version 1 2015-03-19, 00:00

journal contribution

posted on 2015-05-06, 14:43 authored by De-Sheng Ning, Li-yan Peng, Shi-Hong Lv, Dian-Peng Li, Zheng-Hong Pan

A new daphnane diterpenoid, venenatin (1), along with six known compounds, was isolated from the aerial parts of Excoecaria venenata. The structure of 1 was elucidated on the basis of extensive spectroscopic analysis. Compound 1 exhibited growth inhibitory effect on human leukaemia HL-60 cell line with IC₅₀ value of 28.10 μM.