A new coumarin from stem bark of <i>Calophyllum wallichianum</i>

<p>A phytochemical study carried out on the plant, <i>Calophyllum wallichianum</i> has led to the isolation of a new coumarin, wallimarin T (<b>1</b>) and a known coumarin, calanolide E (<b>2</b>) along with two common triterpenes, friedelin (<b>3</b>) and stigmasterol (<b>4</b>). The structures of these compounds were elucidated with the aid of spectroscopic analyses such as FT-IR, GC-MS, and NMR. MIC assay against the <i>Bacillus</i> bacteria were conducted on the extracts and this gave MIC values ranging from 0.313 to 1.25 mg/mL. Compound <b>2</b> was weakly inhibitory towards the <i>Bacilli</i> strains with MIC values ranging from 0.25–0.50 mg/mL. Wallimarin T <b>(1)</b> was not active towards all four bacteria. Overall, the extracts exhibited weak bactericidal properties whereas compound <b>2</b> was not bactericidal on the tested bacteria. The hexane and chloroform extracts of the plant were found to be inhibitors to the growth of <i>Bacillus megaterium</i>, <i>Bacillus cereus</i>, <i>Bacillus pumilus</i> and <i>Bacillus subtilis</i>.</p>