A new androstanoid metabolite from a soil fungus <i>Curvularia borreriae</i> strain HS-FG-237

<p>A new androstanoid metabolite, 4<i>α</i>-methyl-9<i>α</i>-methoxyandrosta-8,15-diene-3,17-dione (<b>1</b>), was isolated from a soil fungus <i>Curvularia borreriae</i> (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound <b>1</b> exhibited poor cytotoxicity toward HCT-116 cells by CCK-8 assay and weak anti-inflammatory activity in an ANA-1 murine macrophages model.</p>